Molecular Proteomics Laboratory

E. Lau, Y. Han, D. R. Williams, C. T. Thomas, R. Shrestha, J. C. Wu, and M. P. Lam
Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome.
Cell Reports, 29(11), 3751-3765, 2019
alternative splicing mass spectrometry bioinformatics proteoforms
DOI, BibTex

E. Lau, V. Venkatraman, C. T. Thomas, J. C. Wu, J. E. V. Eyk, and M. Lam
Identifying high-priority proteins across the human diseasome using semantic similarity
Journal of Proteome Research, 2018
bioinformatics bibliometrics popular proteins hupo
URL, DOI, BibTex

E. Lau, Q. Cao, M. P. Y. Lam, J. Wang, D. C. M. Ng, B. J. Bleakley, J. M. Lee, D. A. Liem, et al.
Integrated omics dissection of proteome dynamics during cardiac remodeling
Nat Commun, 9(1), 2018
mass spectrometry bioinformatics protein turnover proteostasis
BibTex

M. P. Lam, V. Venkatraman, Y. Xing, E. Lau, Q. Cao, D. C. Ng, A. I. Su, J. Ge, et al.
Data-driven approach to determine popular proteins for targeted proteomics translation of six organ systems
J. Proteome Res., 15(11), 2016
bibliometrics hupo
BibTex

E. Lau, Q. Cao, D. C. Ng, B. J. Bleakley, T. U. Dincer, B. M. Bot, D. Wang, D. A. Liem, et al.
A large dataset of protein dynamics in the mammalian heart proteome
Sci Data, 3, 2016
protein turnover heavy water mass spectrometry
BibTex

M. P. Lam, E. Lau, D. C. Ng, D. Wang, and P. Ping
Cardiovascular proteomics in the era of big data: experimental and computational advances
Clin Proteomics, 13, 2016
BibTex

M. P. Lam, V. Venkatraman, Q. Cao, D. Wang, T. U. Dincer, E. Lau, A. I. Su, Y. Xing, et al.
Prioritizing proteomics assay development for clinical translation
J. Am. Coll. Cardiol., 66(2), 2015
BibTex

E. Lau, D. Huang, Q. Cao, T. U. Dincer, C. M. Black, A. J. Lin, J. M. Lee, D. Wang, et al.
Spatial and temporal dynamics of the cardiac mitochondrial proteome
Expert Rev Proteomics, 12(2), 2015
protein turnover cardiovascular mitochondria
BibTex

D. Wang, D. A. Liem, E. Lau, D. C. Ng, B. J. Bleakley, M. Cadeiras, M. C. Deng, M. P. Lam, et al.
Characterization of human plasma proteome dynamics using deuterium oxide
Proteomics Clin Appl, 8(78), 2014
protein turnover human plasma heavy water
BibTex

N. Zong, P. Ping, E. Lau, H. J. Choi, D. C. Ng, D. Meyer, C. Fang, H. Li, et al.
Lysine ubiquitination and acetylation of human cardiac 20S proteasomes
Proteomics Clin Appl, 8(78), 2014
protein turnover cardiovascular
BibTex

M. P. Lam, D. Wang, E. Lau, D. A. Liem, A. K. Kim, D. C. Ng, X. Liang, B. J. Bleakley, et al.
Protein kinetic signatures of the remodeling heart following isoproterenol stimulation
J. Clin. Invest., 124(4), 2014
protein turnover cardiovascular human plasma heavy water mass spectrometry
BibTex

M. P. Lam, E. Lau, D. A. Liem, and P. Ping
Cyclophilin D and acetylation: a new link in cardiac signaling
Circ. Res., 113(12), 2013
cardiovascular
BibTex

M. P. Lam, E. Lau, S. B. Scruggs, D. Wang, T. Y. Kim, D. A. Liem, J. Zhang, C. M. Ryan, et al.
Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation
J Proteomics, 81, 2013
BibTex

T. Y. Kim, D. Wang, A. K. Kim, E. Lau, A. J. Lin, D. A. Liem, J. Zhang, N. C. Zong, et al.
Metabolic labeling reveals proteome dynamics of mouse mitochondria
Mol. Cell Proteomics, 11(12), 2012
protein turnover heavy water mitochondria mass spectrometry
BibTex

M. P. Lam, S. B. Scruggs, T. Y. Kim, C. Zong, E. Lau, D. Wang, C. M. Ryan, K. F. Faull, et al.
An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue
J Proteomics, 75(15), 2012
BibTex

J. Zhang, A. Lin, J. Powers, M. P. Lam, C. Lotz, D. Liem, E. Lau, D. Wang, et al.
Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation
J. Gen. Physiol., 139(6), 2012
BibTex

E. Lau, D. Wang, J. Zhang, H. Yu, M. P. Lam, X. Liang, N. Zong, T. Y. Kim, et al.
Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria
Circ. Res., 110(9), 2012
protein turnover cardiovascular mitochondria
BibTex

M. P. Lam, E. Lau, S. O. Siu, D. C. Ng, R. P. Kong, P. C. Chiu, W. S. Yeung, C. Lo, et al.
Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples
Electrophoresis, 32(21), 2011
BibTex

S. O. Siu, M. P. Lam, E. Lau, R. P. Kong, S. M. Lee, and I. K. Chu
Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics
Proteomics, 11(11), 2011
BibTex

E. Lau, M. P. Lam, S. O. Siu, R. P. Kong, W. L. Chan, Z. Zhou, J. Huang, C. Lo, et al.
Combinatorial use of offline SCX and online RP-RP liquid chromatography for iTRAQ-based quantitative proteomics applications
Mol Biosyst, 7(5), 2011
BibTex

M. P. Lam, S. O. Siu, E. Lau, X. Mao, H. Z. Sun, P. C. Chiu, W. S. Yeung, D. M. Cox, et al.
Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization
Anal Bioanal Chem, 398(2), 2010
BibTex

H. Liu, E. Lau, M. P. Lam, H. Chu, S. Li, G. Huang, P. Guo, J. Wang, et al.
OsNOA1/RIF1 is a functional homolog of AtNOA1/RIF1: implication for a highly conserved plant cGTPase essential for chloroplast function
New Phytol., 187(1), 2010
BibTex

S. O. Siu, M. P. Lam, E. Lau, W. S. Yeung, D. M. Cox, and I. K. Chu
N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry
Methods Mol. Biol., 600, 2010
BibTex

JOURNAL ARTICLES BY E. LAU

CONFERENCE PAPERS

BOOK CHAPTERS

ADVANCED PUBLICATIONS ON BIORXIV

What does oxidative stress do …

Alternative splice isoform companion data …

Popular protein manuscript released on …

Lab receives 5-year R01 funding

BioArXiV article on Gene Annotation …