Molecular Proteomics Laboratory

Y. Han, S. A. Wennersten, J. M. Wright, R. W. Ludwig, E. Lau, and M. P. Y. Lam
Proteogenomics Reveals Sex-biased Aging Genes and Coordinated Splicing in Cardiac Aging
Am J Physiol Heart Circ Physiol, 1(3233), H538-H558, 2022
URL, DOI, BibTex

Y. H. Lin, J. L. Major, T. Liebner, Z. Hourani, J. G. Travers, S. A. Wennersten, K. R. Haefner, M. A. Cavasin, et al.
HDAC6 modulates myofibril stiffness and diastolic function of the heart.
J Clin Invest., 2022
URL, BibTex

Y. Han, L. Z. Li, N. L. Kastury, C. T. Thomas, M. P. Y. Lam, and E. Lau
Transcriptome features of striated muscle aging and predictability of protein level changes
Mol Omics, 2021
URL, BibTex

Y. Han, C. T. Thomas, S. A. Wennersten, E. Lau, and M. P. Y. Lam
Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot
J Vis Exp, 2021
URL, BibTex

J. G. Travers, S. A. Wennersten, B. Peña, R. A. Bagchi, H. E. Smith, R. A. Hirsch, L. A. Vanderlinden, Y. H. Lin, et al.
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
Circulation, 2021
URL, BibTex

T. Chour, L. Tian, E. Lau, D. Thomas, Itzhaki I, O. Malak, J. Z. Zhang, X. Qin, et al.
Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies
JCI Insight, 2021
URL, BibTex

Y. Han, S. D. Wood, J. M. Wright, V. Dostal, E. Lau, and M. P. Y. Lam
Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart
J Mol Cell Cardiol, 154, 92-96, 2021
isoforms proteomics
URL, BibTex

Y. Han, J. M. Wright, E. Lau, and M. P. Y. Lam
Determining Alternative Protein Isoform Expression Using RNA Sequencing and Mass Spectrometry
STAR Protocols, 1(3), 100138, 2020
proteoforms
URL, DOI, BibTex

S. Adhikari, E. C. Nice, E. W. Deutsch, L. Lane, G. S. Omenn, S. R. Pennington, Y. K. Paik, C. M. Overall, et al.
A high-stringency blueprint of the human proteome
Nature Communications, 11(1), 5301, 2020
hupo
URL, BibTex

Y. Han, S. A. Wennersten, and M. P. Y. Lam
Working the literature harder: what can text mining and bibliometric analysis reveal?
Expert Rev Proteomics, 16(1112), 2019
bioinformatics bibliometrics popular proteins hupo
URL, BibTex

E. Lau, Y. Han, D. R. Williams, C. T. Thomas, R. Shrestha, J. C. Wu, and M. P. Lam
Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome.
Cell Reports, 29(11), 3751-3765, 2019
alternative splicing mass spectrometry bioinformatics proteoforms
DOI, BibTex

C. Ruiz-Romero, M. P. Y. Lam, P. Nilsson, P. Önnerfjord, P. J. Utz, J. E. V. Eyk, Venkatraman V, J. Fert-Bober, et al.
Mining the Proteome Associated with Rheumatic and Autoimmune Diseases.
Journal of Proteome Research, 18(12), 4231-4239, 2019
bioinformatics bibliometrics popular proteins hupo
URL, DOI, BibTex

M. S. Stratton, R. A. Bagchi, M. B. Felisbino, R. A. Hirsch, H. E. Smith, A. S. Riching, B. Y. Enyart, K. A. Koch, et al.
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation
Circ. Res., 125(7), 2019
mass spectrometry fibrosis
DOI, BibTex

E. Lau, V. Venkatraman, C. T. Thomas, J. C. Wu, J. E. V. Eyk, and M. Lam
Identifying high-priority proteins across the human diseasome using semantic similarity
Journal of Proteome Research, 2018
bioinformatics bibliometrics popular proteins hupo
URL, DOI, BibTex

M. P. Y. Lam and Y. Ge
Harnessing the Power of Proteomics to Assess Drug Safety and Guide Clinical Trials
Circulation, 137(10), 2018
BibTex

E. Lau, Q. Cao, M. P. Y. Lam, J. Wang, D. C. M. Ng, B. J. Bleakley, J. M. Lee, D. A. Liem, et al.
Integrated omics dissection of proteome dynamics during cardiac remodeling
Nat Commun, 9(1), 2018
mass spectrometry bioinformatics protein turnover proteostasis
BibTex

M. P. Lam, P. Ping, and E. Murphy
Proteomics research in cardiovascular medicine and biomarker discovery
J. Am. Coll. Cardiol., 68(25), 2016
proteomics cardiovascular
BibTex

M. P. Lam, V. Venkatraman, Y. Xing, E. Lau, Q. Cao, D. C. Ng, A. I. Su, J. Ge, et al.
Data-driven approach to determine popular proteins for targeted proteomics translation of six organ systems
J. Proteome Res., 15(11), 2016
bibliometrics hupo
BibTex

A. Yee, M. P. Lam, V. Tam, W. C. Chan, I. K. Chu, K. S. Cheah, K. M. Cheung, and D. Chan
Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis
Osteoarthr. Cartil., 24(3), 2016
proteomics fibrosis
BibTex

E. Lau, Q. Cao, D. C. Ng, B. J. Bleakley, T. U. Dincer, B. M. Bot, D. Wang, D. A. Liem, et al.
A large dataset of protein dynamics in the mammalian heart proteome
Sci Data, 3, 2016
protein turnover heavy water mass spectrometry
BibTex

L. Lin, P. Jiang, J. W. Park, J. Wang, Z. X. Lu, M. P. Lam, P. Ping, and Y. Xing
The contribution of Alu exons to the human proteome
Genome Biol., 17, 2016
BibTex

M. P. Lam, E. Lau, D. C. Ng, D. Wang, and P. Ping
Cardiovascular proteomics in the era of big data: experimental and computational advances
Clin Proteomics, 13, 2016
BibTex

M. P. Lam, V. Venkatraman, Q. Cao, D. Wang, T. U. Dincer, E. Lau, A. I. Su, Y. Xing, et al.
Prioritizing proteomics assay development for clinical translation
J. Am. Coll. Cardiol., 66(2), 2015
BibTex

E. Lau, D. Huang, Q. Cao, T. U. Dincer, C. M. Black, A. J. Lin, J. M. Lee, D. Wang, et al.
Spatial and temporal dynamics of the cardiac mitochondrial proteome
Expert Rev Proteomics, 12(2), 2015
protein turnover cardiovascular mitochondria
BibTex

D. Wang, D. A. Liem, E. Lau, D. C. Ng, B. J. Bleakley, M. Cadeiras, M. C. Deng, M. P. Lam, et al.
Characterization of human plasma proteome dynamics using deuterium oxide
Proteomics Clin Appl, 8(78), 2014
protein turnover human plasma heavy water
BibTex

N. Zong, P. Ping, E. Lau, H. J. Choi, D. C. Ng, D. Meyer, C. Fang, H. Li, et al.
Lysine ubiquitination and acetylation of human cardiac 20S proteasomes
Proteomics Clin Appl, 8(78), 2014
protein turnover cardiovascular
BibTex

M. P. Lam, D. Wang, E. Lau, D. A. Liem, A. K. Kim, D. C. Ng, X. Liang, B. J. Bleakley, et al.
Protein kinetic signatures of the remodeling heart following isoproterenol stimulation
J. Clin. Invest., 124(4), 2014
protein turnover cardiovascular human plasma heavy water mass spectrometry
BibTex

M. P. Lam, C. H. Law, Q. Quan, Y. Zhao, and I. K. Chu
Fully automatable multidimensional reversed-phase liquid chromatography with online tandem mass spectrometry
Methods Mol. Biol., 1156, 2014
BibTex

M. P. Lam, E. Lau, D. A. Liem, and P. Ping
Cyclophilin D and acetylation: a new link in cardiac signaling
Circ. Res., 113(12), 2013
cardiovascular
BibTex

C. L. Lee, M. P. Lam, K. K. Lam, C. O. Leung, R. T. Pang, I. K. Chu, T. H. Wan, J. Chai, et al.
Identification of CD147 (basigin) as a mediator of trophoblast functions
Hum. Reprod., 28(11), 2013
BibTex

N. C. Zong, H. Li, H. Li, M. P. Lam, R. C. Jimenez, C. S. Kim, N. Deng, A. K. Kim, et al.
Integration of cardiac proteome biology and medicine by a specialized knowledgebase
Circ. Res., 113(9), 2013
BibTex

M. P. Lam, E. Lau, S. B. Scruggs, D. Wang, T. Y. Kim, D. A. Liem, J. Zhang, C. M. Ryan, et al.
Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation
J Proteomics, 81, 2013
BibTex

B. S. Wong, K. K. Lam, C. L. Lee, V. H. Wong, M. P. Lam, I. K. Chu, W. S. Yeung, and P. C. Chiu
Adrenomedullin enhances invasion of human extravillous cytotrophoblast-derived cell lines by regulation of urokinase plasminogen activator expression and s-nitrosylation
Biol. Reprod., 88(2), 2013
BibTex

T. Y. Kim, D. Wang, A. K. Kim, E. Lau, A. J. Lin, D. A. Liem, J. Zhang, N. C. Zong, et al.
Metabolic labeling reveals proteome dynamics of mouse mitochondria
Mol. Cell Proteomics, 11(12), 2012
protein turnover heavy water mitochondria mass spectrometry
BibTex

M. P. Lam, S. B. Scruggs, T. Y. Kim, C. Zong, E. Lau, D. Wang, C. M. Ryan, K. F. Faull, et al.
An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue
J Proteomics, 75(15), 2012
BibTex

Y. Zhao, R. P. Kong, G. Li, M. P. Lam, C. H. Law, S. M. Lee, H. C. Lam, and I. K. Chu
Fully automatable two-dimensional hydrophilic interaction liquid chromatography-reversed phase liquid chromatography with online tandem mass spectrometry for shotgun proteomics
J Sep Sci, 35(14), 2012
BibTex

J. Zhang, A. Lin, J. Powers, M. P. Lam, C. Lotz, D. Liem, E. Lau, D. Wang, et al.
Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation
J. Gen. Physiol., 139(6), 2012
BibTex

E. Lau, D. Wang, J. Zhang, H. Yu, M. P. Lam, X. Liang, N. Zong, T. Y. Kim, et al.
Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria
Circ. Res., 110(9), 2012
protein turnover cardiovascular mitochondria
BibTex

M. P. Lam, F. Vivanco, A. Scholten, H. Hermjakob, J. V. Eyk, and P. Ping
HUPO 2011: The new Cardiovascular Initiative - integrating proteomics and cardiovascular biology in health and disease
Proteomics, 12(6), 2012
BibTex

M. P. Lam, E. Lau, S. O. Siu, D. C. Ng, R. P. Kong, P. C. Chiu, W. S. Yeung, C. Lo, et al.
Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples
Electrophoresis, 32(21), 2011
BibTex

S. O. Siu, M. P. Lam, E. Lau, R. P. Kong, S. M. Lee, and I. K. Chu
Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics
Proteomics, 11(11), 2011
BibTex

E. Lau, M. P. Lam, S. O. Siu, R. P. Kong, W. L. Chan, Z. Zhou, J. Huang, C. Lo, et al.
Combinatorial use of offline SCX and online RP-RP liquid chromatography for iTRAQ-based quantitative proteomics applications
Mol Biosyst, 7(5), 2011
BibTex

M. P. Lam, S. O. Siu, E. Lau, X. Mao, H. Z. Sun, P. C. Chiu, W. S. Yeung, D. M. Cox, et al.
Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization
Anal Bioanal Chem, 398(2), 2010
BibTex

H. Liu, E. Lau, M. P. Lam, H. Chu, S. Li, G. Huang, P. Guo, J. Wang, et al.
OsNOA1/RIF1 is a functional homolog of AtNOA1/RIF1: implication for a highly conserved plant cGTPase essential for chloroplast function
New Phytol., 187(1), 2010
BibTex

S. O. Siu, M. P. Lam, E. Lau, W. S. Yeung, D. M. Cox, and I. K. Chu
N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry
Methods Mol. Biol., 600, 2010
BibTex

JOURNAL ARTICLES BY M. P. LAM

CONFERENCE PAPERS

BOOK CHAPTERS

ADVANCED PUBLICATIONS ON BIORXIV