University of Colorado School of Medicine
Medicine/Cardiology
CFReT
Maggie P.Y. Lam, PhD
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JOURNAL ARTICLES BY M. P. LAM
Y. H. Lin
,
J. L. Major
,
T. Liebner
,
Z. Hourani
,
J. G. Travers
,
S. A. Wennersten
,
K. R. Haefner
,
M. A. Cavasin
,
et al.
HDAC6 modulates myofibril stiffness and diastolic function of the heart.
J Clin Invest., 2022
URL
,
BibTex
Y. Han
,
L. Z. Li
,
N. L. Kastury
,
C. T. Thomas
,
M. P. Y. Lam
,
and
E. Lau
Transcriptome features of striated muscle aging and predictability of protein level changes
Mol Omics, 2021
URL
,
BibTex
Y. Han
,
C. T. Thomas
,
S. A. Wennersten
,
E. Lau
,
and
M. P. Y. Lam
Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot
J Vis Exp, 2021
URL
,
BibTex
J. G. Travers
,
S. A. Wennersten
,
B. Peña
,
R. A. Bagchi
,
H. E. Smith
,
R. A. Hirsch
,
L. A. Vanderlinden
,
Y. H. Lin
,
et al.
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
Circulation, 2021
URL
,
BibTex
T. Chour
,
L. Tian
,
E. Lau
,
D. Thomas
,
Itzhaki I
,
O. Malak
,
J. Z. Zhang
,
X. Qin
,
et al.
Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies
JCI Insight, 2021
URL
,
BibTex
Y. Han
,
S. D. Wood
,
J. M. Wright
,
V. Dostal
,
E. Lau
,
and
M. P. Y. Lam
Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart
J Mol Cell Cardiol,
154
, 92-96, 2021
isoforms
proteomics
URL
,
BibTex
Y. Han
,
J. M. Wright
,
E. Lau
,
and
M. P. Y. Lam
Determining Alternative Protein Isoform Expression Using RNA Sequencing and Mass Spectrometry
STAR Protocols,
1
(3), 100138, 2020
proteoforms
URL
,
DOI
,
BibTex
S. Adhikari
,
E. C. Nice
,
E. W. Deutsch
,
L. Lane
,
G. S. Omenn
,
S. R. Pennington
,
Y. K. Paik
,
C. M. Overall
,
et al.
A high-stringency blueprint of the human proteome
Nature Communications,
11
(1), 5301, 2020
hupo
URL
,
BibTex
Y. Han
,
S. A. Wennersten
,
and
M. P. Y. Lam
Working the literature harder: what can text mining and bibliometric analysis reveal?
Expert Rev Proteomics,
16
(1112), 2019
bioinformatics
bibliometrics
popular proteins
hupo
URL
,
BibTex
E. Lau
,
Y. Han
,
D. R. Williams
,
C. T. Thomas
,
R. Shrestha
,
J. C. Wu
,
and
M. P. Lam
Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome.
Cell Reports,
29
(11), 3751-3765, 2019
alternative splicing
mass spectrometry
bioinformatics
proteoforms
DOI
,
BibTex
C. Ruiz-Romero
,
M. P. Y. Lam
,
P. Nilsson
,
P. Önnerfjord
,
P. J. Utz
,
J. E. V. Eyk
,
Venkatraman V
,
J. Fert-Bober
,
et al.
Mining the Proteome Associated with Rheumatic and Autoimmune Diseases.
Journal of Proteome Research,
18
(12), 4231-4239, 2019
bioinformatics
bibliometrics
popular proteins
hupo
URL
,
DOI
,
BibTex
M. S. Stratton
,
R. A. Bagchi
,
M. B. Felisbino
,
R. A. Hirsch
,
H. E. Smith
,
A. S. Riching
,
B. Y. Enyart
,
K. A. Koch
,
et al.
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation
Circ. Res.,
125
(7), 2019
mass spectrometry
fibrosis
DOI
,
BibTex
E. Lau
,
V. Venkatraman
,
C. T. Thomas
,
J. C. Wu
,
J. E. V. Eyk
,
and
M. Lam
Identifying high-priority proteins across the human diseasome using semantic similarity
Journal of Proteome Research, 2018
bioinformatics
bibliometrics
popular proteins
hupo
URL
,
DOI
,
BibTex
M. P. Y. Lam
and
Y. Ge
Harnessing the Power of Proteomics to Assess Drug Safety and Guide Clinical Trials
Circulation,
137
(10), 2018
BibTex
E. Lau
,
Q. Cao
,
M. P. Y. Lam
,
J. Wang
,
D. C. M. Ng
,
B. J. Bleakley
,
J. M. Lee
,
D. A. Liem
,
et al.
Integrated omics dissection of proteome dynamics during cardiac remodeling
Nat Commun,
9
(1), 2018
mass spectrometry
bioinformatics
protein turnover
proteostasis
BibTex
M. P. Lam
,
P. Ping
,
and
E. Murphy
Proteomics research in cardiovascular medicine and biomarker discovery
J. Am. Coll. Cardiol.,
68
(25), 2016
proteomics
cardiovascular
BibTex
M. P. Lam
,
V. Venkatraman
,
Y. Xing
,
E. Lau
,
Q. Cao
,
D. C. Ng
,
A. I. Su
,
J. Ge
,
et al.
Data-driven approach to determine popular proteins for targeted proteomics translation of six organ systems
J. Proteome Res.,
15
(11), 2016
bibliometrics
hupo
BibTex
A. Yee
,
M. P. Lam
,
V. Tam
,
W. C. Chan
,
I. K. Chu
,
K. S. Cheah
,
K. M. Cheung
,
and
D. Chan
Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis
Osteoarthr. Cartil.,
24
(3), 2016
proteomics
fibrosis
BibTex
E. Lau
,
Q. Cao
,
D. C. Ng
,
B. J. Bleakley
,
T. U. Dincer
,
B. M. Bot
,
D. Wang
,
D. A. Liem
,
et al.
A large dataset of protein dynamics in the mammalian heart proteome
Sci Data,
3
, 2016
protein turnover
heavy water
mass spectrometry
BibTex
L. Lin
,
P. Jiang
,
J. W. Park
,
J. Wang
,
Z. X. Lu
,
M. P. Lam
,
P. Ping
,
and
Y. Xing
The contribution of Alu exons to the human proteome
Genome Biol.,
17
, 2016
BibTex
M. P. Lam
,
E. Lau
,
D. C. Ng
,
D. Wang
,
and
P. Ping
Cardiovascular proteomics in the era of big data: experimental and computational advances
Clin Proteomics,
13
, 2016
BibTex
M. P. Lam
,
V. Venkatraman
,
Q. Cao
,
D. Wang
,
T. U. Dincer
,
E. Lau
,
A. I. Su
,
Y. Xing
,
et al.
Prioritizing proteomics assay development for clinical translation
J. Am. Coll. Cardiol.,
66
(2), 2015
BibTex
E. Lau
,
D. Huang
,
Q. Cao
,
T. U. Dincer
,
C. M. Black
,
A. J. Lin
,
J. M. Lee
,
D. Wang
,
et al.
Spatial and temporal dynamics of the cardiac mitochondrial proteome
Expert Rev Proteomics,
12
(2), 2015
protein turnover
cardiovascular
mitochondria
BibTex
D. Wang
,
D. A. Liem
,
E. Lau
,
D. C. Ng
,
B. J. Bleakley
,
M. Cadeiras
,
M. C. Deng
,
M. P. Lam
,
et al.
Characterization of human plasma proteome dynamics using deuterium oxide
Proteomics Clin Appl,
8
(78), 2014
protein turnover
human plasma
heavy water
BibTex
N. Zong
,
P. Ping
,
E. Lau
,
H. J. Choi
,
D. C. Ng
,
D. Meyer
,
C. Fang
,
H. Li
,
et al.
Lysine ubiquitination and acetylation of human cardiac 20S proteasomes
Proteomics Clin Appl,
8
(78), 2014
protein turnover
cardiovascular
BibTex
M. P. Lam
,
D. Wang
,
E. Lau
,
D. A. Liem
,
A. K. Kim
,
D. C. Ng
,
X. Liang
,
B. J. Bleakley
,
et al.
Protein kinetic signatures of the remodeling heart following isoproterenol stimulation
J. Clin. Invest.,
124
(4), 2014
protein turnover
cardiovascular
human plasma
heavy water
mass spectrometry
BibTex
M. P. Lam
,
C. H. Law
,
Q. Quan
,
Y. Zhao
,
and
I. K. Chu
Fully automatable multidimensional reversed-phase liquid chromatography with online tandem mass spectrometry
Methods Mol. Biol.,
1156
, 2014
BibTex
M. P. Lam
,
E. Lau
,
D. A. Liem
,
and
P. Ping
Cyclophilin D and acetylation: a new link in cardiac signaling
Circ. Res.,
113
(12), 2013
cardiovascular
BibTex
C. L. Lee
,
M. P. Lam
,
K. K. Lam
,
C. O. Leung
,
R. T. Pang
,
I. K. Chu
,
T. H. Wan
,
J. Chai
,
et al.
Identification of CD147 (basigin) as a mediator of trophoblast functions
Hum. Reprod.,
28
(11), 2013
BibTex
N. C. Zong
,
H. Li
,
H. Li
,
M. P. Lam
,
R. C. Jimenez
,
C. S. Kim
,
N. Deng
,
A. K. Kim
,
et al.
Integration of cardiac proteome biology and medicine by a specialized knowledgebase
Circ. Res.,
113
(9), 2013
BibTex
M. P. Lam
,
E. Lau
,
S. B. Scruggs
,
D. Wang
,
T. Y. Kim
,
D. A. Liem
,
J. Zhang
,
C. M. Ryan
,
et al.
Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation
J Proteomics,
81
, 2013
BibTex
B. S. Wong
,
K. K. Lam
,
C. L. Lee
,
V. H. Wong
,
M. P. Lam
,
I. K. Chu
,
W. S. Yeung
,
and
P. C. Chiu
Adrenomedullin enhances invasion of human extravillous cytotrophoblast-derived cell lines by regulation of urokinase plasminogen activator expression and s-nitrosylation
Biol. Reprod.,
88
(2), 2013
BibTex
T. Y. Kim
,
D. Wang
,
A. K. Kim
,
E. Lau
,
A. J. Lin
,
D. A. Liem
,
J. Zhang
,
N. C. Zong
,
et al.
Metabolic labeling reveals proteome dynamics of mouse mitochondria
Mol. Cell Proteomics,
11
(12), 2012
protein turnover
heavy water
mitochondria
mass spectrometry
BibTex
M. P. Lam
,
S. B. Scruggs
,
T. Y. Kim
,
C. Zong
,
E. Lau
,
D. Wang
,
C. M. Ryan
,
K. F. Faull
,
et al.
An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue
J Proteomics,
75
(15), 2012
BibTex
Y. Zhao
,
R. P. Kong
,
G. Li
,
M. P. Lam
,
C. H. Law
,
S. M. Lee
,
H. C. Lam
,
and
I. K. Chu
Fully automatable two-dimensional hydrophilic interaction liquid chromatography-reversed phase liquid chromatography with online tandem mass spectrometry for shotgun proteomics
J Sep Sci,
35
(14), 2012
BibTex
J. Zhang
,
A. Lin
,
J. Powers
,
M. P. Lam
,
C. Lotz
,
D. Liem
,
E. Lau
,
D. Wang
,
et al.
Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation
J. Gen. Physiol.,
139
(6), 2012
BibTex
E. Lau
,
D. Wang
,
J. Zhang
,
H. Yu
,
M. P. Lam
,
X. Liang
,
N. Zong
,
T. Y. Kim
,
et al.
Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria
Circ. Res.,
110
(9), 2012
protein turnover
cardiovascular
mitochondria
BibTex
M. P. Lam
,
F. Vivanco
,
A. Scholten
,
H. Hermjakob
,
J. V. Eyk
,
and
P. Ping
HUPO 2011: The new Cardiovascular Initiative - integrating proteomics and cardiovascular biology in health and disease
Proteomics,
12
(6), 2012
BibTex
M. P. Lam
,
E. Lau
,
S. O. Siu
,
D. C. Ng
,
R. P. Kong
,
P. C. Chiu
,
W. S. Yeung
,
C. Lo
,
et al.
Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples
Electrophoresis,
32
(21), 2011
BibTex
S. O. Siu
,
M. P. Lam
,
E. Lau
,
R. P. Kong
,
S. M. Lee
,
and
I. K. Chu
Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics
Proteomics,
11
(11), 2011
BibTex
E. Lau
,
M. P. Lam
,
S. O. Siu
,
R. P. Kong
,
W. L. Chan
,
Z. Zhou
,
J. Huang
,
C. Lo
,
et al.
Combinatorial use of offline SCX and online RP-RP liquid chromatography for iTRAQ-based quantitative proteomics applications
Mol Biosyst,
7
(5), 2011
BibTex
M. P. Lam
,
S. O. Siu
,
E. Lau
,
X. Mao
,
H. Z. Sun
,
P. C. Chiu
,
W. S. Yeung
,
D. M. Cox
,
et al.
Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization
Anal Bioanal Chem,
398
(2), 2010
BibTex
H. Liu
,
E. Lau
,
M. P. Lam
,
H. Chu
,
S. Li
,
G. Huang
,
P. Guo
,
J. Wang
,
et al.
OsNOA1/RIF1 is a functional homolog of AtNOA1/RIF1: implication for a highly conserved plant cGTPase essential for chloroplast function
New Phytol.,
187
(1), 2010
BibTex
S. O. Siu
,
M. P. Lam
,
E. Lau
,
W. S. Yeung
,
D. M. Cox
,
and
I. K. Chu
N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry
Methods Mol. Biol.,
600
, 2010
BibTex
CONFERENCE PAPERS
M. P. Lam
,
P. Ping
,
and
Y. Xing
Integrated omics analysis of isoform switching under cardiac hypertrophy
Journal of Molecular and Cellular Cardiology,
112
, 164-165, 2017
alternative splicing
proteoforms
DOI
,
BibTex
E. Lau
,
M. P. Lam
,
and
P. Ping
Multi-omics approach to identify disease signatures in cardiac remodeling
Journal of Molecular and Cellular Cardiology,
112
, 154-155, 2017
BibTex
BOOK CHAPTERS
E. Lau
and
M. P. Y. Lam
Research trends and focuses in the ubiquitin-proteasome system: a bibliometric analysis
Ubiquitin Proteasome System: A Review and Directions for Research. (Series: Cell Biology Research Progress), Nova Publishers, 2018, ISBN 978-1-53613-518-3
book chapter
protein turnover
URL
,
ISBN
,
BibTex
ADVANCED PUBLICATIONS ON BIORXIV
H. Srivastava
,
R. Canfield
,
M. P. Lam
,
and
E. Lau
Post-transcriptional regulation of protein abundance by protein interaction partners
bioRxiv, 2022
URL
,
BibTex
Y. Han
,
S. A. Wennersten
,
J. Wright
,
R. W. Ludwig
,
E. Lau
,
and
M. P. Lam
Proteogenomic characterization of age and sex interactions in cardiac gene expression
bioRxiv, 2022
URL
,
BibTex
V. Dostal
,
S. D. Wood
,
C. T. Thomas
,
E. Y. Han
,
E. Lau
,
and
M. P. Y. Lam
Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart
bioRxiv, 2020
heart
proteomics
oxidative stress
proteostasis
URL
,
DOI
,
BibTex
E. Lau
and
M. P. Y. Lam
Identifying alternative splicing isoforms in the human proteome with small proteotranscriptomic databases
bioRxiv, 2018
preprint
alternative splicing
mass spectrometry
bioinformatics
proteoforms
URL
,
DOI
,
BibTex
E. Lau
,
V. Venkatraman
,
C. T. Thomas
,
J. E. V. Eyk
,
and
M. P. Y. Lam
Identifying high-priority proteins across the human diseasome using semantic similarity
bioRxiv, 2018
preprint
popular proteins
bibliometrics
URL
,
DOI
,
BibTex